we reviewed metformin-as-primary-prevention-of-obesity-diabetes-and-the-other-major-common-degenerative-diseases-of-aging on 3 March 2008, and have regularly posted updates on why it should be used preventitively instead of waiting perversely and negligently till so much damage is done that diabetes – or its myriad complications- finally present clinically..
Now a coalition in Atlanta Georgia has published a detailed evaluation of why at least 24 million Americans with prediabetes by strict criteria should be on preventative metformin. And that 1 in 12 adults are only the tip of the iceberg of people at risk, the over 50% who are now at risk overweight (BMI > 25kg/sqm) let alone obese (BMI > 27kg), if they dont already have either raised bloodpressure, lipidemia, vascular disease, or raised fasting glucose/ insulin or impaired glucose tolerance ie bloodsugar after a meal…
Since metformin is the only drug proven in 20year randomized controlled trial (UKPDS) in new older diabetics to reduce all-cause morbidity and deaths by a third, and in 4 major prevention trials (China, USA, India, Greece) to reduce new diabetes by between 30% and 80%)- without the slightest increase in serious risks - it has long been clear that it is negligent not to prescribe it with appropriate instruction about dose titration from the outset, (and with other appropriate supplements- fish oil, vitamins, minerals, and other natural biologicals -like appropriate HRT and CoQ10, carnitine etc, and herbs) - to reduce all complications and motivate, energize the patient better to comply with diet and lifestyle advice. .
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